A skull base encephalocele occurs when brain tissue and its coverings herniate through a defect in the skull base, often causing clear nasal drainage, headaches that worsen when upright, or recurrent infections. Treatment typically involves endoscopic endonasal repair with a multilayer graft to re-establish a watertight seal.

ABS surgeons repair these defects using image guidance and tissue grafts to prevent cerebrospinal fluid (CSF) leaks and infections.